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The Ca 2+ entry mechanisms in ECs play important roles in this process, as evidenced by the observations that removal of extracellular Ca 2+ or inhibition of CaM suppresses agonist-induced NO production (Forstermann et al., 1991

This NAD + -sparing effect can enhance the metabolic fitness and function of effector immune cells, reversing a key mechanism of myeloid-driven immune evasion